en تخصصي Special پژوهشي Research <div style="text-align: justify;"><strong>Background</strong>: The COVID-19 epidemic was a biological disaster that may cause or exacerbate burnout in healthcare professionals (HCPs). Our goal was to determine the impact of the long-term COVID-19 epidemic on burnout in front-line healthcare workers and the factors affecting it.<br> <strong>Materials and Methods:</strong> This cross-sectional survey on front-line HCPs&rsquo; job burnout based on an online platform was conducted at Mazandaran University of Medical Sciences. The demographic characteristics, medical-work-related factors, and COVID-19 exposure were collected by the self-reported Farsi version of the Maslach burnout inventory questionnaire.<br> <strong>Results</strong>: Out of 2100 sent questionnaires, 924 participants completed them (44% response rate) of which 280 were male (30.3%). Overall, 850(92%) respondents had a high level of emotional exhaustion, 872(94.4%) had a high level of depersonalization, and 112(12.1%) had a high reduced personal accomplishment. There was a significant relation between higher burnout levels with higher education levels, working in hospitals as clinical staff, and pre-hospital operational personnel as well as having direct contact with a significant number of COVID-19 Patients. A significant number of participants (94.2%) were in severe and moderate burnout levels.<br> <strong>Conclusion</strong>: There was a significant increase in job burnout among front-line HCPs during the COVID-19 epidemic compared to former similar studies at the beginning of the epidemic and non-epidemic periods. It is recommended that in disaster management planning, especially in long-standing ones like COVID-19, the proper programs should be considered for increasing the resilience of HCPs.</div> Health personnel, SARS-CoV-2, COVID-19, Burnout, Iran 157 166 http://hdq.uswr.ac.ir/browse.php?a_code=A-10-34-5&slc_lang=en&sid=1 Reza Habibisaravi rhabibisaravi@mazums.ac.ir 0000-0003-3279-3693 No Pre-Hospital Emergency Medical Services and Disaster Management Center, Mazandaran University of Medical Sciences, Sari, Iran. Fariba Ghasemihamedani fghasemihamedani@gmail.com 0000-0002-5904-6017 No Health Management and Economics Research Center, Iran University of Medical Sciences, Tehran, Iran. Ghasem Oveis dr.oveis@yahoo.com 0000-0002-4790-4299 No Department of Public Health, Faculty of Health, Mazandaran University of Medical Sciences, Sari, Iran. Sadi Azizi sadiazizi1395@gmail.com 0000-0003-2088-4483 No Vice Chancellor of Treatment, Mazandaran University of Medical Sciences, Sari, Iran. Touraj Assadi t.asadi@mazums.ac.ir 0000-0003-2336-6470 Yes Department of Emergency Medicine, Faculty of Medicine, Mazandaran University of Medical Sciences, Sari, Iran.