en اورژانس Emergency پژوهشي Research <div style="text-align: justify;"><strong>Background</strong>: The rising incidence of healthcare-associated infections underscores the need for strict adherence to standard precautions. The prehospital emergency service is the initial contact point for patients, where infection risks can start. This study was conducted to evaluate the factors influencing adherence to standard precautions among prehospital emergency personnel.<br> <strong>Materials and Methods</strong>: This descriptive-analytical cross-sectional study was conducted in 2023. Data were collected using a demographic questionnaire and the compliance with standard precautions scale. Statistical analysis was performed using SPSS software, version 25 and Kolmogorov-Smirnov, chi-square, Fisher exact test, and Spearman correlation. P<0.05 was considered statistically significant.<br> <strong>Results</strong>: This study of 206 prehospital emergency personnel in Tehran found low compliance with standard precautions (mean score: 13.27&plusmn;3.38). Standard precaution compliance was significantly and positively associated with marital status, history of health check-ups, history of exposure to body fluids, and the quality of personal protective equipment &nbsp;(PPE), with higher compliance observed among individuals possessing these characteristics. No significant links were found with base type (urban/rural) or PPE access. Weak, non-significant correlations were observed with age (r=-0.031, P=0.668) and work experience (r=-0.075, P=0.292).<br> <strong>Discussion</strong>: Given the low compliance with standard precautions among prehospital emergency personnel and the rise of emerging and antibiotic-resistant infectious diseases, developing specialized infection control policies and strategies tailored to prehospital emergency care is imperative.<br> Conclusion: Improving adherence to standard precautions among prehospital emergency personnel is crucial. Strengthening the factors influencing adherence can enhance infection control from the initial stage of medical service delivery.</div> Emergency medical services (EMS), Standard precautions, Occupational hazards, Infection control, Compliance, Personal protective equipment (PPE), Healthcare-associated infections 201 208 http://hdq.uswr.ac.ir/browse.php?a_code=A-10-179-6&slc_lang=en&sid=1 Yasaman Jahed yasamanjahed1373@gmail.com 0009-0009-8493-2502 No Department of Medical Surgical Nursing, School of Nursing and Midwifery, Tehran University of Medical Sciences, Tehran, Iran. Mahdi Nabi Foodani mahdi.nabi7575@gmail.com 0000-0002-5359-3589 No Nursing and Midwifery Care Research Center, Tehran University of Medical Sciences, Tehran, Iran Saeed Mehrsorosh Saied1755@gmail.com No Department of Head of Education, Tehran Emergency Organization, Tehran, Iran. Zahra Abbasi Dolatabadi Zahra_abasi2000@yahoo.com 0000-0003-1290-5272 Yes Department of Medical Surgical Nursing, School of Nursing and Midwifery, Tehran University of Medical Sciences, Tehran, Iran.