en عمومى General پژوهشي Research <div style="text-align: justify;"><strong>Background</strong>: Emergency service workers experience extreme psychological stress as they are the first to respond to accidents and disasters, and this can deplete their quality of life (QoL).Resilience plays a very significant role in enabling individuals to cope with stress effectively without detracting from physical and psychological well-being. The objective of this study was to evaluate the status of resilience and establish its correlation with QoL and spiritual well-being among nurses working in in-hospital and pre-hospital emergency departments.<br> <strong>Materials and Methods</strong>: This cross-sectional study was carried out in 2024 across four hospitals affiliated with Mashhad University of Medical Sciences. A total of 212 emergency nurses were recruited using a cluster sampling approach. Each hospital was considered a cluster; four hospitals were randomly chosen, and data were collected from these hospitals through convenience sampling with proportional allocation based on job categories. Data collection instruments were a demographic questionnaire and three standardized questionnaires: the Paloutzian and Ellison&rsquo;s Spiritual Health Questionnaire (20&ndash;120), the Connor-Davidson Resilience Scale (0&ndash;100), and the World Health Organization (WHO) QoL questionnaire (0&ndash;100). Data were analyzed using inferential statistics (Mann-Whitney U tests, t-tests, chi-square tests, Fisher&rsquo;s exact tests, Spearman correlation analysis) utilizing SPSS software, version 26.<br> <strong>Results</strong>: The response rate was 70%. The participants&rsquo; spiritual health was moderate (mean =72.28&plusmn;15.85), as indicated for 96.7% of the participants. The mean scores for QoL (83.89&plusmn;17.01) and resilience (58.72&plusmn;15.72) indicated moderate levels among the participants. Religious health had a higher score than existential health. Environmental health had the highest mean score among the quality-of-life facets, whereas personal competence had the highest mean score among the resilience facets. Positive correlations were observed among QoL, resilience, and spiritual health (P<0.001). Spiritual health and resilience had direct effects on individuals&rsquo; QoL.&nbsp;<br> <strong>Conclusion</strong>: Emergency nurses demonstrated moderate levels of resilience, spiritual health, and QoL, and these variables were positively correlated. Interventions that enhance spiritual health and promote resilience can be effective in improving their QoL.</div> Resilience, Spiritual health, Quality of life (QoL), Emergency services, Emergency nurses, Pre-hospital emergency care 61 70 http://hdq.uswr.ac.ir/browse.php?a_code=A-10-697-1&slc_lang=en&sid=1 Maryam Salari salarimr@mums.ac.ir 0000-0002-4944-3422 No Department of Biostatistics, School of Health, Mashhad University of Medical Sciences, Mashhad, Iran. Fatemeh Kokabi-Saghi Kokabisf@mums.ac.ir No Social Determinants of Health Research Center, Mashhad University of Medical Sciences, Mashhad, Iran. Fatemeh Dorri Khalilzadeh DorriKF4022@mums.ac.ir No Student Research Committee, Mashhad University of Medical Sciences, Mashhad, Iran. Hamidreza Shabanikiya ShabaniKiaHR@mums.ac.ir 0000-0002-8592-6018 Yes Social Determinants of Health Research Center, Mashhad University of Medical Sciences, Mashhad, Iran.