Background: This study aimed to model the relationship between occupational accidents, work-family conflict, and quality of work-life in emergency room nurses.
Materials and Methods: This correlational research uses path analysis. The study population consisted of all nurses working in the emergency rooms of hospitals in Tehran City, Iran, in 2020. Of them, 200 samples were selected by the available sampling method. To obtain the data, we used the occupational accidents questionnaire, the quality of work-life questionnaire, and the work-family conflict scale. SPSS v. 24 and Amos v. 24 software were used for data analysis.
Results: The analysis of the findings showed that occupational accidents and work-family conflict have a negative and direct effect on the quality of work-life (P<0.01). Occupational accidents also have a positive and direct effect on work-family conflict (P<0.01). On the other hand, the mediating role of work-family conflict between occupational accidents and quality of work-life was confirmed (P<0.01).
Conclusion: The relationship model of occupational accidents with quality of work-life mediated by work-family conflict has a good fit, and there is a relationship between family, job, and environmental stressors with the quality of work-life.

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