Background: According to the World Health Organization, preventive measures are the only non-pharmacological method to combat the COVID-19 epidemic. This study aimed to investigate the relationship between perceived social support and preventive behaviors mediated by the variables of life expectancy and mental wellbeing.
Materials and Methods: This study is applied in terms of purpose and was conducted by survey method. The statistical population included women living in Tehran City, Iran, with a sample size of 428. The study data were collected using the preventive behavior scale, mental wellbeing scale, Snyder hope scale, and multidimensional perceived social support scale. The obtained data were analyzed using SPSS 25 and AMOS 23 software.
Results: The study results showed a positive and significant relationship between perceived social support and mental wellbeing, between perceived social support and life expectancy, and between mental wellbeing and life expectancy. Also, life expectancy and mental wellbeing variables mediate between perceived social support and preventive behaviors.
Conclusion: Considering the critical role of women in family management and preventive measures during the COVID-19 epidemic, strengthening social support networks, hope, and mental wellbeing should be considered.

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